Lymphangioma of popliteal fossa masquerading as Baker’s cyst

Abstract

Background

Lymphatic malformations are the second most common vascular malformations after venous malformations. These slow-flow lesions occur most often in the paediatric population and seldom in the extremities. We report a case of lymphangioma at the popliteal fossa in an adult who underwent complete surgical resection.

Case presentation

A 30-year-old male presented to the department of orthopaedics with a swelling in the right calf region. Clinically, it was suspected to be a Baker’s cyst. Ultrasound showed a multiloculated anechoic cystic lesion in the inferior aspect of popliteal fossa along the intermuscular plane with multiple internal septations. Infected Baker’s cyst was considered, and MRI was suggested for further evaluation. On MRI, the lesion measured 7.2 × 4.6 × 5.8 cm, appeared as a low signal on T1 and high signal on STIR and T2, with multiple internal septations and was situated in the inferior aspect of the right popliteal fossa along the intermuscular plane between the lateral head of gastrocnemius and soleus muscles. No obvious synovial extension. A post-contrast study showed minimal peripheral and septal enhancement. Neither internal enhancing solid components nor significant internal derangement of the knee was observed. Diagnosis of lymphangioma was considered based on the imaging features and ruling out the common differentials for cystic lesions around the knee. Wide local excision was performed. Histopathological evaluation showed multiple irregularly dilated lymphatic channels lined by flatted epithelium. The lymphatic channels were seen to be surrounded by thick fibro collagenous cyst wall with scattered congested blood vessels, skeletal muscle fibre and chronic inflammatory cells.

Conclusion

Lymphangioma must be included in the differential diagnosis of any cystic lesion if the lesion appears multiseptated and/or infiltrative. At the popliteal fossa, it presents as a multiseptated cyst with no synovial continuity or internal derangement of the knee.

Background

Lymphatic malformations are the second most common vascular malformations after venous malformations. Lymphatic malformations are commonly known as cystic hygromas or lymphangiomas. These slow-flow lesions occur most often in the paediatric population and seldom in the extremities. It tends to occur predominantly in the neck and axilla. Diagnosis must be considered in cases of multiseptated cysts. Lymphangiomas generally do not show significant post-contrast enhancement. Post-contrast enhancement can be seen in mixed types like veno-lymphatic malformations. These lesions tend to infiltrate into the surrounding tissues rather than displacing them. We report a case of lymphangioma at the popliteal fossa in an adult who underwent complete surgical resection.

Case presentation

A 30-year-old male presented to the department of orthopaedics with a swelling in the right calf region for 2 years, which was painful for a month (Figs. 1, 2, 3, 4, 5, and 6). Clinically, it was suspected to be an infected Baker’s cyst and was referred for radiological evaluation.

Fig. 1

Thirty-year-old male with lymphangioma in the proximal leg along the posterior aspect. Findings: axial (a) and sagittal (b) T2WI images at the level of the proximal leg showing a multiloculated high-signal intensity lesion in the intermuscular plane between the soleus (yellow arrow) and lateral head of the gastrocnemius muscles (yellow asterisk). Multiple thin internal septations seen within predominantly in the superior aspect (red arrow). The lesion appears to be away from the joint with no intra-articular continuation. Technique: Philips Insta 1.5-T MRI—T2WI axial and sagittal: TR 4843 ms, TE 100 ms, matrix 324 × 260 and slice thickness 3 mm

Fig. 2

Thirty-year-old male with lymphangioma in the proximal leg along the posterior aspect. Findings: FLAIR axial (a) and T1WI sagittal (b) images showing the lesion in the intermuscular plane which appears as a low signal on T1WI (yellow arrow) and shows homogenous suppression on FLAIR (red arrow). Fat plane is maintained with the adjacent muscles (white arrow). Technique: Philips Insta 1.5-T MRI—FLAIR axial: TR 11,000 ms, TE 120 ms, TI 2800 ms, matrix 256 × 144 and slice thickness 3 mm; T1WI axial: TR 522 ms, TE 18 ms, matrix 380 × 258 and slice thickness 3 mm

Fig. 3

Thirty-year-old male with lymphangioma in the proximal leg along the posterior aspect. Findings: coronal (a) and sagittal (b) STIR images. The lesion shows a high signal (red asterisk). Adjacent muscle show normal signal, suggestive of a lack of perilesional inflammation. Technique: Philips Insta 1.5-T MRI—STIR coronal and sagittal: TR 3762 ms, TE 80 ms, TI 150 ms, matrix 240 × 168 and slice thickness 3 mm

Fig. 4

Thirty-year-old male with lymphangioma in the proximal leg along the posterior aspect. Findings: coronal (a) and sagittal (b) post-contrast fat saturation images showing enhancing capsule (red arrow) and internal septae (yellow arrow). No enhancing mural components/papillary projections are seen within. No enhancement is seen in the adjacent muscles. Technique: Philips Insta 1.5-T MRI—fat-saturated, post-Gd T1WI: TR 522 ms, TE 18 ms, matrix 380 × 258 and slice thickness 3 mm (contrast used—diamagnetic contrast—gadobutrol 10 ml)

Fig. 5

Intraoperative image showing a pearly white well-encapsulated cystic lesion in the intermuscular plane. The lesion was separated from the neurovascular bundle and had no continuity with the joint

Fig. 6

Histopathology image showing multiple irregularly dilated lymphatic channels

On ultrasound, a multiloculated anechoic cystic lesion was noted in the inferior aspect of the popliteal fossa along the intermuscular plane with multiple internal septations. No significant internal vascularity was noted. Minimal internal echoes were seen within. Infected Baker’s cyst was considered and MRI was suggested for further evaluation.

On MRI, the lesion measured 7.2 × 4.6 × 5.8 cm, appeared as a low signal on T1 and high signal on STIR and T2. It was well defined with multiple internal septations and was situated in the inferior aspect of the right popliteal fossa along the intermuscular plane between the lateral head of gastrocnemius and soleus muscles, with no obvious synovial extension. No adjacent inflammatory changes were present. The lesion showed minimal peripheral and septal enhancement on the post-contrast study. No enhancing solid components or internal derangement of the knee was observed. Diagnosis of lymphangioma was considered based on the imaging features and ruling out the common differentials for cystic lesions around the knee.

Wide local excision was performed. Intra-operatively, the lesion appeared to be a pearly white well-encapsulated cyst in the intermuscular plane. It was separate from the neurovascular bundle and had no continuity with the joint.

Histopathological evaluation showed multiple irregularly dilated lymphatic channels lined by flatted epithelium. The lymphatic channels were seen to be surrounded by thick fibro collagenous cyst wall with scattered congested blood vessels, skeletal muscle fibre and chronic inflammatory cells.

Discussion

Lymphatic malformations are the second most common malformations after venous malformations [1]. Lymphatic malformations are commonly known as cystic hygromas or lymphangiomas. These slow-flow lesions occur most often in the paediatric population and seldom in the extremities [2]. Common cystic lesions in and around the popliteal fossa are meniscal cyst, synovial cyst (Baker’s cyst) and ganglionic cyst. Lymphangioma at popliteal fossa has been rarely reported [3]. The most common types of vascular malformations are venous, lymphatic and venolymphatic with an overall prevalence of up to 1% in the general population [4]. Lymphangioma may involve almost every organ system, soft-tissue lymphatic malformations most commonly occurring in cervicofacial (up to 75% of cases), axillary (up to 25%), or mediastinal (3–10%) areas [2]. Approximately 95% of lymphangiomas are found in the neck and axilla, and the other 5% occur in the mediastinum and abdominal cavity, including the mesentery, retroperitoneum and bones [5]. The aetiology of lymphangiomas is still unclear. They are considered to be congenital dysplasia of lymphatic tissue and abnormal development of the lymphatic vessels during foetal life [6, 7].

The occurrence of lymphangiomas in the upper and lower limbs has been published in a few case reports [8]. Males and females are equally affected. Generally, the presentation of the lymphangiomas may be with symptoms related to the local effect or painless swelling. A clinical examination may reveal soft non-tender masses on palpation with a doughy consistency.

On ultrasound, lymphangioma appears as a multilocular anechoic cystic mass with internal septa of varying thickness located in the intermuscular plane. The appearance of the cyst is variable depending on the presence or absence of secondary infection. Wide variations exist such as cystic mass with solid areas or mostly solid with cystic foci.

Most of the lymphangiomas appear homogenous on CT scan, but some appear inhomogeneous due to the presence of the proteinaceous, fluid, blood or fat components. Minimal displacement or compression of the adjacent structures might be seen.

On MR imaging, lymphatic malformations appear as multiseptated cystic masses that can infiltrate surrounding tissues, sometimes causing hypertrophy of the affected body part. The cysts are typically hypointense on T1-weighted images and hyperintense on T2-weighted images [2]. More heterogeneous signal intensity may be seen within cysts with proteinaceous or haemorrhagic content. The cysts do not characteristically enhance, although the septa, which are vascularised, show contrast material uptake. There may also be enhancement of the venous component in mixed malformations. In the microcystic form, the cysts may not be visible as distinct elements, and the lesion may appear slightly hyperintense after gadolinium administration due to septal enhancement [2].

The two main strategies used to treat lymphatic anomalies are sclerotherapy and surgical resection. Sclerotherapy works through the obliteration of the lymphatic lumen [9]. Sclerotherapy agents like bleomycin, doxycycline and OK 432 have been used particularly in large lesions and those located in inaccessible areas [8]. Ozeki et al. have advocated the use of propranolol (a beta-blocker) as an adjunct in treating intractable lymphatic malformations [10].

A cystic mass arising in the popliteal fossa can be either a meniscal cyst, a synovial cyst (Baker’s cyst) or a ganglionic cyst.

Synovial cysts result from the extrusion of joint fluid into the gastrocnemius and the semimembranosus bursa through a weak portion of the posteromedial capsule of the knee between the medial head of the gastrocnemius muscle and the semimembranosus tendon [2]. Visualising a communicating fluid collection arising between the tendons of the medial head of the gastrocnemius and semimembranosus is the key to making a diagnosis.

Ganglionic cysts are soft tissue masses caused by the myxoid degeneration of the connective tissue at the joint capsules and tendon sheaths [11]. The ganglia demonstrate low-signal intensity on T1W images and high-signal intensity on T2W images and may show rim enhancement.

Meniscal cysts are believed to form as a result of tears in the meniscal fibrocartilage, with the extrusion of synovial fluid through the meniscal tear. Meniscal cysts have low signal intensity on T1W images and increased signal intensity on fluid sensitive sequences and may show peripheral contrast enhancement [12].

Lymphangiomas are uncommon vascular malformations with the posterior triangle of the neck being the most common site. Meniscal cyst, synovial cyst (Baker’s cyst) and ganglionic cyst are common differentials for cystic lesions in the popliteal fossa. Lymphangioma should be suspected if the lesion appears multiseptated with no synovial continuity or internal derangement of the knee.

Conclusion

Lymphangioma must be included in the differential diagnosis of any cystic lesion if the lesion appears multiseptated and/or infiltrative (Table 1). At the popliteal fossa, it presents as a multiseptated cyst with no synovial continuity or internal derangement of the knee. Lymphangioma has no specific imaging features; still should be considered in the differential diagnosis if Baker’s cyst is not evident.

Table 1 Differential diagnosis for cystic lesions in and around the popliteal fossa